Substitute. Nice word. Think teachers and recipes. And stuff that tries to taste like coffee but

Substitute. Nice word. Think teachers and recipes. And stuff that tries to taste like coffee but isn’t. Welcome to our new and improved comments, which are for subscribers only. This is a test to see whether we can improve the experience for you. You do not need a Facebook profile to participate. You will need to register before adding a comment. Typed comments will be lost if you are not logged in. Please be polite. It’s OK to disagree with someone’s ideas, but personal attacks, insults, threats, hate speech, advocating violence and other violations can result in a ban. If you see comments in violation of our community guidelines, please report them. Substitute. Nice word. Think teachers and recipes. And stuff that tries to taste like coffee but isn’t. I’m drinking chicory coffee at the moment – quality coffee blended with an endearing substitute. Mmmm. Takes me back to New Orleans. I’m looking out an RV window that’s temporarily sealed against the elements with clear tape on all edges because the caulking failed. This will be the second winter for the tape. It may have more staying power than the original sealant, like a third-string quarterback who proves himself...

Pretreatment with β-Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction: Role of eNOS Activation

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Vascular endothelial cells play an important role in modulating anti-thrombus and maintaining the natural function of vascular by secreting many active substances. β-boswellic acid (β-BA) is an active triterpenoid compound from the extract of boswellia serrate. In this study, it is demonstrated that β-BA ameliorates plasma coagulation parameters, protects endothelium from blood stasis induced injury and prevents blood stasis induced impairment of endothelium-dependent vasodilatation. Moreover, it is found that β-BA significantly increases nitric oxide (NO) and cyclic guanosine 3’, 5’-monophosphate (cGMP) levels in carotid aortas of blood stasis rats. To stimulate blood stasis-like conditions in vitro, human umbilical vein endothelial cells (HUVECs) were exposed to transient oxygen and glucose deprivation (OGD). Treatment of β-BA significantly increase...

The Best Netflix Original Movies, Ranked Search Close Search Close

Netflix has spent the last few years and several billions of dollars on a crusade to be taken more seriously. Ever since it began branding its logo on original films in 2015, Netflix’s primary goal has been to divorce itself from the “digital dollar bin” reputation it established upon first pivoting from the snail-mail service, now an unsettlingly faint memory, to streaming. It was not so long ago that the service formerly known as “Netflix Instant” well, sucked; it was a repository for direct-to-DVD sequels, little-seen stand-up specials, and candy-colored kiddie cartoons seemingly plucked from Lisa Frank’s more vivid night terrors. And so Netflix exec Ted Sarandos made a dignified selection for his first narrative go on the silver screen: Beasts of No Nation, a movie about child militias in Africa, with a well-pedigreed creative team (Cary Fukunaga was comin’ in hot off his True Detective stint, Idris Elba was a brand-name star) and their according awards potential. It’s a real movie, and by my count, a pretty good one. The second film they released was the one where a donkey explosively sharts all over Adam Sandler. Since then, Netflix has bagged an Oscar, elbowed its way int...

No piece of furniture says “me time” quite like a chaise longue. With its reclined back

No piece of furniture says “me time” quite like a chaise longue. With its reclined back and elevated feet, it offers the promise of serenity in a package designed for just one person. “It’s great for creating a secondary space that’s tucked away and a little more private” than a home’s social spaces, said Corie Sharples, a founding partner of New York-based SHoP Architects, where she leads the interiors group. A chaise longue is ideal in a library, a corner of the master bedroom or an alcove off the living room. And because it usually sits by itself, it can be more sculptural than other pieces of furniture. Of course, because it’s so comfortable, it also runs the risk of being monopolized by unintended users. The chaise longue in Ms. Sharples’s home, for instance, has been claimed by the dogs: “It’s where they like to play king of the hill.” Does a chaise longue need to have an eye-catching shape? Not necessarily, Ms. Sharples said, but “definitely look for something with some personality, whether it’s the material, the stitching, a little added detail or the bolster.” How much floor space do you need? A lot. Consider not only the footprint of the piece, but also room for climb...

Flexible submental sensor patch with remote monitoring controls for management of oropharyngeal swallowing disorders

Successful rehabilitation of oropharyngeal swallowing disorders (i.e., dysphagia) requires frequent performance of head/neck exercises that primarily rely on expensive biofeedback devices, often only available in large medical centers. This directly affects treatment compliance and outcomes, and highlights the need to develop a portable and inexpensive remote monitoring system for the telerehabilitation of dysphagia. Here, we present the development and preliminarily validation of a skin-mountable sensor patch that can fit on the curvature of the submental (under the chin) area noninvasively and provide simultaneous remote monitoring of muscle activity and laryngeal movement during swallowing tasks and maneuvers. This sensor patch incorporates an optimal design that allows for the accurate recording of submental muscle activity during swallowing and is characterized by ease of use, accessibility, reusability, and cost-effectiveness. Preliminary studies on a patient with Parkinson’s disease and dysphagia, and on a healthy control participant demonstrate the feasibility and effectiveness of this system. Successful completion of a swallow requires the precise coordination of more t...

Letting slower passengers board airplane first really is faster, study finds

Commercial airlines often prioritize boarding for passengers traveling with small children, or for those who need extra assistance—in other words, those likely to be slower to stow their bags and take their seats—before starting to board the faster passengers. It’s counter-intuitive, but it turns out that letting slower passengers board first actually results in a more efficient process and less time before takeoff, according to a new paper in Physical Review E. Physicists have been puzzling over this particular optimization problem for several years now. While passengers all have reserved seats, they arrive at the gate in arbitrary order, and over the years, airlines have tried any number of boarding strategies to make the process as efficient and timely as possible. Flight delays have a ripple effect on the complex interconnected network of air travel and often result in extra costs and disgruntled passengers. Back in 2011, Jason Steffen, now a physicist at the University of Nevada, Las Vegas, became intrigued by the problem and applied the same optimization routine used to solve the famous traveling salesman problem to airline boarding strategies. Steffen fully expected...

ZK International Group Co Ltd (NASDAQ:ZKIN) Short Interest Update

ZK International Group Co Ltd (NASDAQ:ZKIN) was the target of a large decline in short interest in December. As of December 31st, there was short interest totalling 51,200 shares, a decline of 14.2% from the December 15th total of 59,700 shares. Currently, 1.4% of the company’s stock are sold short. Based on an average daily trading volume, of 39,000 shares, the short-interest ratio is presently 1.3 days. A hedge fund recently raised its stake in ZK International Group stock. Renaissance Technologies LLC raised its stake in shares of ZK International Group Co Ltd (NASDAQ:ZKIN) by 90.3% in the second quarter, according to its most recent 13F filing with the SEC. The fund owned 353,781 shares of the company’s stock after purchasing an additional 167,837 shares during the period. Renaissance Technologies LLC owned approximately 2.14% of ZK International Group worth $503,000 as of its most recent SEC filing. 2.75% of the stock is currently owned by institutional investors. Shares of ZK International Group stock opened at $1.57 on Wednesday. ZK International Group has a one year low of $1.05 and a one year high of $4.18. The business has a 50-day simple moving average of $1.35 and a ...

Cinelli réédite un ensemble cintre et potence qui a marqué l’histoire du vélo

Partager la publication “Cinelli réédite un ensemble cintre et potence qui a marqué l’histoire du vélo” Partager la publication “Cinelli réédite un ensemble cintre et potence qui a marqué l’histoire du vélo” - 48 ans. – Journaliste professionnel depuis 1992 – Coach / Accompagnement de la performance – Ancien coureur Elite – Pratiques sportives actuelles : route & allroad (un peu). – Strava : Guillaume Judas CNC Lathe Machining, CNC Milling Machining, Custom Service – Microvision,https://www.micprecision.com/